polC
M129
DNA polymerase III, leading strand polymerase (alpha subunit)
locus
MPN034
function
DNA replication
product
DNA polymerase III, leading strand polymerase (alpha subunit),
MW
158730
ec
2.7.7.7
pI
7.42
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
41131 → 36800 (-)
the protein
catalyzed reaction/ biological activity
2´-deoxyribonucleoside 5´-triphosphate + (deoxynucleotides)(n) = (deoxynucleotides)(n+1) + PPi, reversible reaction
localization
cytoplasm (according to UniProt)
modification
Acetylated in Lysine, at K1411 [pubmed|22373819]
Acetylated in Lysine, at K197 [pubmed|22373819]
Phosphorylated in Ser/Thr, at T998, T1001 [pubmed|22373819]
cofactors
Mg2+
Zn2+
structure
[PDB|3F2B] from Geobacillus kaustophilus, DNA Polymerase complex with DNA, dGTP, Mg and Zn (43% identity) [pubmed|19106298]
[AF|P75080]
references
reviews
original publications
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Time of last update: 2025-04-23 14:39:23
Author of last update: Jstuelk