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R21: D-fructose[e] + protein N(pi)-phospho-L-histidine = D-fructose 1-phosphate + protein L-histidineD-fructose 1-phosphateprotein L-histidineD-fructose[e]protein N(pi)-phospho-L-histidineFruAR1: protein L-histidine + phosphoenolpyruvate = protein N(pi)-phospho-L-histidine + pyruvateprotein N(pi)-phospho-L-histidinepyruvateprotein L-histidinephosphoenolpyruvatePtsIR23: D-fructose 1-phosphate = glycerone phosphate + D-glyceraldehydeglycerone phosphateD-glyceraldehydeD-fructose 1-phosphateFbaR24: D-glyceraldehyde + NADH + H+ = D-glycerol + NAD+D-glycerolNAD+H+D-glyceraldehydeNADHAdhR192: D-glycerol [e] = D-glycerolD-glycerolD-glycerol [e]GlpFR49: D-glycerol + ATP = ADP + D-glycerol 3-phosphateADPD-glycerol 3-phosphateATPD-glycerolGlpKR186: 2 D-glycerol 3-phosphate + O2 = 2 glycerone phosphate + H2O2glycerone phosphateH2O2D-glycerol 3-phosphateO2GlpOR206: O2[e] = O2O2O2[e]R211: H2O2[e] = H2O2H2O2H2O2[e]R53: acyl-[acyl-carrier protein] + sn-glycerol 3-phosphate = [acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate1-acyl-sn-glycerol 3-phosphate[acyl-carrier protein]D-glycerol 3-phosphateacyl-[acyl-carrier protein]PlsYR54: acyl-[acyl-carrier protein] + 1-acyl-sn-glycerol 3-phosphate = [acyl-carrier protein] + 1,2-diacyl-sn-glycerol 3-phosphate1,2-diacyl-sn-glycerol 3-phosphate[acyl-carrier protein]acyl-[acyl-carrier protein]1-acyl-sn-glycerol 3-phosphatePlsCR452: 1,2-diacyl-sn-glycerol 3-phosphate + CTP <=> CDP-diacylglycerol + diphosphateCDP-diacylglyceroldiphosphateCTP1,2-diacyl-sn-glycerol 3-phosphateCdsAR56: CDP-diacylglycerol + D-glycerol 3-phosphate = 3(3-phosphatidyl-)L-glycerol 1-phosphate + CMP3(3-phosphatidyl-)L-glycerol 1-phosphateCMPD-glycerol 3-phosphateCDP-diacylglycerolPgsAR57: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphatephosphatephosphatidylglycerolH2O3(3-phosphatidyl-)L-glycerol 1-phosphateR58: phosphatidylglycerol + CDP-diacylglycerol = cardiolipin + CMPCMPcardiolipinCDP-diacylglycerolphosphatidylglycerolR59: phosphatidate + H2O = 1,2-diacyl-sn-glycerol + phosphatephosphate1,2-diacyl-sn-glycerolH2O1,2-diacyl-sn-glycerol 3-phosphateLip3R64: UDP-galactose + 1,2-diacyl-sn-glycerol = UDP + D-galactosyl-1,2-diacylglycerolUDPD-galactosyl-1,2-diacylglycerolUDP-galactose1,2-diacyl-sn-glycerolYibDR428: L-1,2-diacylglycerol + UDP-glucose = D-glucosyl-1,2-diacylglycerol + UDPUDPD-glucosyl-1,2-diacylglycerolUDP-glucose1,2-diacyl-sn-glycerolYibDR2: D-glucose[e] + protein N(pi)-phospho-L-histidine = D-glucose 6-phosphate + protein L-histidineD-glucose 6-phosphateprotein L-histidineprotein N(pi)-phospho-L-histidineD-glucose[e]PtsGR1: protein L-histidine + phosphoenolpyruvate = protein N(pi)-phospho-L-histidine + pyruvateprotein N(pi)-phospho-L-histidinepyruvateprotein L-histidinephosphoenolpyruvatePtsIR60: D-glucose 1-phosphate = D-glucose 6-phosphateD-glucose 6-phosphateD-glucose 1-phosphateCpsGR61: D-glucose 1-phosphate + UTP = UDP-glucose + PPiUDP-glucoseD-glucose 1-phosphateUTPGtaBR62: UDP-glucose = UDP-galactoseUDP-galactoseUDP-glucoseGalER3: D-glucose 6-phosphate = D-fructose 6-phosphateD-fructose 6-phosphateD-glucose 6-phosphatePgiBR26: D-mannose[e] + protein N(pi)-phospho-L-histidine = D-mannose 6-phosphate + protein L-histidineD-mannose 6-phosphateprotein L-histidineprotein N(pi)-phospho-L-histidineD-mannose[e]FruAR1: protein L-histidine + phosphoenolpyruvate = protein N(pi)-phospho-L-histidine + pyruvateprotein N(pi)-phospho-L-histidinepyruvateprotein L-histidinephosphoenolpyruvatePtsIR28: D-mannose 6-phosphate = D-fructose 6-phosphateD-fructose 6-phosphateD-mannose 6-phosphateR27: D-mannose 1-phosphate = D-mannose 6-phosphateD-mannose 6-phosphateD-mannose 1-phosphateCpsGR4: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphateADPD-fructose 1,6-bisphosphateATPD-fructose 6-phosphatePfkR5: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphateglycerone phosphateD-glyceraldehyde 3-phosphateD-fructose 1,6-bisphosphateFbaR6: D-glyceraldehyde 3-phosphate = glycerone phosphateglycerone phosphateD-glyceraldehyde 3-phosphateTpiAR7: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+H+NADH3-phospho-D-glyceroyl phosphatephosphateD-glyceraldehyde 3-phosphateNAD+GapR8: 3-phospho-D-glyceroyl phosphate + ADP = 3-phospho-D-glycerate + ATPATP3-phospho-D-glycerateADP3-phospho-D-glyceroyl phosphatePgkR9: 3-phospho-D-glycerate = 2-phospho-D-glycerate2-phospho-D-glycerate3-phospho-D-glyceratePgmR10: 2-phospho-D-glycerate = phosphoenolpyruvate + H2OH2Ophosphoenolpyruvate2-phospho-D-glycerateEnoR11: phosphoenolpyruvate + ADP = pyruvate + ATPATPpyruvateADPphosphoenolpyruvatePykR15: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2CO2S-acetyldihydrolipoamidepyruvatelipoamidePdhAR16: S-acetyldihydrolipoamide + CoA = dihydrolipoamide + acetyl-CoAdihydrolipoamideacetyl-CoACoAS-acetyldihydrolipoamidePdhCR17: dihydrolipoamide + NAD+ = lipoamide + NADH + H+H+NADHlipoamideNAD+dihydrolipoamidePdhDR12: pyruvate + NADH + H+ = (S)-lactate + NAD+NAD+(S)-lactateH+NADHpyruvateLdhR430: phosphatidylcholine[e] + H2O + ATP = phosphatidylcholine + ADP + Pi + H+ADPH+phosphatidylcholinePiATPH2Ophosphatidylcholine[e]R187: phosphatidylcholine + 2 H2O = glycerophosphocholine + 2 fatty acidglycerophosphocholinefatty acidH2OphosphatidylcholineLip3R182: glycerophosphocholine + H2O = choline + D-glycerol 3-phosphateD-glycerol 3-phosphatecholineH2OglycerophosphocholineGlpQR178: choline + ATP = choline phosphate + ADPADPcholine phosphateATPcholineLicAR180: choline phosphate + CTP = CDP-choline + pyrophosphateCDP-cholinepyrophosphateCTPcholine phosphateNadDR218: pantetheine[e] = pantetheinepantetheinepantetheine[e]R145: pantetheine + ATP = pantetheine 4'-phosphate + ADPADPpantetheine 4'-phosphateATPpantetheineR146: pantetheine 4'-phosphate + ATP = dephospho-CoA + PPiPPidephospho-CoAATPpantetheine 4'-phosphateNadDR147: dephospho-CoA + ATP = CoA + ADPADPCoAATPdephospho-CoACoaER149: holo-[acyl-carrier protein] + H2O = pantetheine 4'-phosphate + apo-[acyl-carrier protein]apo-[acyl-carrier protein]pantetheine 4'-phosphateH2Oholo-[acyl-carrier protein]AcpHR148: apo-[acyl-carrier protein] + CoA= holo-[acyl-carrier protein] + adenosine 3',5'-bisphosphateholo-[acyl-carrier protein]adenosine 3',5'-bisphosphateapo-[acyl-carrier protein]CoAAcpSR150: fatty acid + holo-[acyl-carrier protein] + ATP = acyl-[acyl-carrier protein] + AMP + PPiAMPPPiacyl-[acyl-carrier protein]holo-[acyl-carrier protein]fatty acidR188: adenosine 3',5'-bisphosphate + H2O = AMP + phosphateAMPphosphateH2Oadenosine 3',5'-bisphosphateR267: phosphate --> phosphate[e]phosphate[e]phosphateR453: phosphate[e] + ATP + H2O = H+ + ADP + phosphateADPphosphateH+ATPphosphate[e]H2OPhosphate transport systemPhoUPstBPstAPstSR217: nicotinate[e] = nicotinatenicotinatenicotinate[e]R136: nicotinate + 5-phospho-D-ribose 1-PPi = nicotinate D-ribonucleotide + PPiPPinicotinate D-ribonucleotide5-phospho-D-ribose 1-PPinicotinatePncBR137: nicotinate D-ribonucleotide + ATP = deamido-NAD+ + PPiPPideamido-NAD+ATPnicotinate D-ribonucleotideNadDR138: deamido-NAD+ + ATP + NH3 = NAD+ + AMP + PPiAMPPPiNAD+ATPNH3deamido-NAD+OutBR139: NAD+ + ATP = NADP+ + ADPADPNADP+ATPNAD+PpnKR213: folate[e] = folatefolatefolate[e]R194: folate + NADH + H+ = dihydrofolate + NAD+NAD+dihydrofolateH+NADHfolateDhfrDyrR126: dihydrofolate + NADH + H+ = tetrahydrofolate + NAD+tetrahydrofolateNAD+H+NADHdihydrofolateDhfrR127: tetrahydrofolate + formate + ATP = 10-formyltetrahydrofolate + ADP + phosphateADP10-formyltetrahydrofolatephosphateATPtetrahydrofolateformateMtd1R129: L-methionyl-tRNAfMet + 10-formyltetrahydrofolate + H2O = N-formylmethionyl-tRNAfMet + tetrahydrofolatetetrahydrofolateN-formylmethionyl-tRNAfMet10-formyltetrahydrofolateH2OL-methionyl-tRNAfMetFmtR128: 10-formyltetrahydrofolate + H+ = 5,10-methenyltetrahydrofolate + H2O5,10-methenyltetrahydrofolateH2O10-formyltetrahydrofolateH+Mtd1R130: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serineL-serinetetrahydrofolateH2O5,10-methylenetetrahydrofolateglycineGlyAR131: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+H+5,10-methenyltetrahydrofolateNADPH5,10-methylenetetrahydrofolateNADP+Mtd1R431: dUMP + 5,10-methylenetetrahydrofolate = dTMP + dihydrofolatedTMPdihydrofolatedUMP5,10-methylenetetrahydrofolateThyAR226: acetate + H+[e] = acetate[e] + H+[e]H+acetateH+[e]acetate[e]R19: acetyl phosphate + ADP = acetate + ATPATPacetateADPacetyl phosphateAckAR18: acetyl-CoA + phosphate = CoA + acetyl phosphateCoAacetyl phosphatephosphateacetyl-CoAPtaR47: acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+acetaldehydeCoAH+NADHacetyl-CoAAdhR48: acetaldehyde + NADH + H+ = ethanol + NAD+NAD+ethanolH+acetaldehydeNADHAdhR46: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehydeD-glyceraldehyde 3-phosphateacetaldehyde2-deoxy-D-ribose 5-phosphateDeoCR44: 2-deoxy-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate2-deoxy-D-ribose 5-phosphate2-deoxy-D-ribose 1-phosphateCpsGR29: D-mannitol[e] + protein N(pi)-phospho-L-histidine = D-mannitol 1-phosphate + protein L-histidineprotein L-histidineD-mannitol 1-phosphateprotein N(pi)-phospho-L-histidineD-mannitol[e]MtlFR1: protein L-histidine + phosphoenolpyruvate = protein N(pi)-phospho-L-histidine + pyruvateprotein N(pi)-phospho-L-histidinepyruvateprotein L-histidinephosphoenolpyruvatePtsIR30: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+H+D-fructose 6-phosphateNADHNAD+D-mannitol 1-phosphateMtlDR191: D-ribose[e] + ATP + H2O = D-ribose + ADP + phosphateADPphosphateD-riboseATPH2OD-ribose[e]R36: D-ribose + ATP = D-ribose 5-phosphate + ADPADPD-ribose 5-phosphateATPD-riboseR43: D-ribose 1-phosphate = D-ribose 5-phosphateD-ribose 5-phosphateD-ribose 1-phosphateCpsGR39: D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphateD-ribose 5-phosphateD-xylulose 5-phosphateD-glyceraldehyde 3-phosphateD-sedoheptulose 7-phosphateTklBR38: D-erythrose 4-phosphate + D-fructose 6-phosphate = D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphateD-glyceraldehyde 3-phosphateD-sedoheptulose 7-phosphateD-fructose 6-phosphateD-erythrose 4-phosphateR37: D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + D-erythrose 4-phosphateD-xylulose 5-phosphateD-erythrose 4-phosphateD-glyceraldehyde 3-phosphateD-fructose 6-phosphateTklBR7: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+H+NADH3-phospho-D-glyceroyl phosphatephosphateD-glyceraldehyde 3-phosphateNAD+GapR8: 3-phospho-D-glyceroyl phosphate + ADP = 3-phospho-D-glycerate + ATPATP3-phospho-D-glycerateADP3-phospho-D-glyceroyl phosphatePgkR9: 3-phospho-D-glycerate = 2-phospho-D-glycerate2-phospho-D-glycerate3-phospho-D-glyceratePgmR10: 2-phospho-D-glycerate = phosphoenolpyruvate + H2OH2Ophosphoenolpyruvate2-phospho-D-glycerateEnoR11: phosphoenolpyruvate + ADP = pyruvate + ATPATPpyruvateADPphosphoenolpyruvatePykR40: D-ribulose 5-phosphate = D-xylulose 5-phosphateD-xylulose 5-phosphateD-ribulose 5-phosphateCfxER41: D-ribose 5-phosphate = D-ribulose 5-phosphateD-ribulose 5-phosphateD-ribose 5-phosphateRpiBR42: D-ribose 5-phosphate + ATP = 5-phospho-D-ribose 1-PPi + AMPAMP5-phospho-D-ribose 1-PPiATPD-ribose 5-phosphatePrsR31: L-ascorbate[e] + protein N(pi)-phospho-L-histidine = L-ascorbate 6-phosphate + protein L-histidineprotein L-histidineL-ascorbate 6-phosphateprotein N(pi)-phospho-L-histidineL-ascorbate[e]UlaAR1: protein L-histidine + phosphoenolpyruvate = protein N(pi)-phospho-L-histidine + pyruvateprotein N(pi)-phospho-L-histidinepyruvateprotein L-histidinephosphoenolpyruvatePtsIR32: L-ascorbate 6-phosphate + H2O = 3-dehydro-L-gulonate 6-phosphate3-dehydro-L-gulonate 6-phosphateH2OL-ascorbate 6-phosphateUlaGR33: 3-dehydro-L-gulonate 6-phosphate + H+ = L-xylulose 5-phosphate + CO2CO2L-xylulose 5-phosphateH+3-dehydro-L-gulonate 6-phosphateUlaDR34: L-ribulose 5-phosphate = L-xylulose 5-phosphateL-xylulose 5-phosphateL-ribulose 5-phosphateUlaER35: L-ribulose 5-phosphate = D-xylulose 5-phosphateD-xylulose 5-phosphateL-ribulose 5-phosphateAraDR216: adenine + H+ = adenine[e] + H+[e]H+adenineH+[e]adenine[e]R66: adenosine + phosphate = adenine + D-ribose 1-phosphateadenineD-ribose 1-phosphatephosphateadenosineDeoDR67: AMP + H2O = adenosine + phosphatephosphateadenosineAMPH2OR68: AMP + ATP = 2 ADPADPATPAMPAdkR11: phosphoenolpyruvate + ADP = pyruvate + ATPATPpyruvateADPphosphoenolpyruvatePykR71: RNAn + NTP = RNAn+1 + PPiPPiRNA(n+1)ATPRNA(n)MPN191;MPN515;MPN516;MPN352RpoARpoCRpoBSigAR73: deoxyadenosine + phosphate = adenine + 2-deoxy-D-ribose 1-phosphateadenine2-deoxy-D-ribose 1-phosphatephosphatedeoxyadenosineDeoDR74: deoxyadenosine + ATP = dAMP + ADPADPdAMPATPdeoxyadenosineYaaFR75: dAMP + ATP = dADP + ADPADPdADPATPdAMPAdkR76: phosphoenolpyruvate + dADP = pyruvate + dATPdATPpyruvatedADPphosphoenolpyruvatePykR454: DNA(n) + dATP = PPi + DNA(n+1)PPiDNA(n+1)dATPDNA(n)PolCR455: ADP + txrB-(R'-SH)2 = dADP + txrB-R'-S-S-R' + H2OH2OdADPtxrB-R'-S-S-R'ADPtxrB-(R'-SH)2Ribonucleoside-diphosphate reductaseNrdFNrdINrdER65: adenine + 5-phospho-D-ribose 1-PPi = AMP + PPiAMPPPi5-phospho-D-ribose 1-PPiadenineAptR210: guanine[e] + H+[e] = guanine + H+H+guanineH+[e]guanine[e]R79: guanosine + phosphate = guanine + D-ribose 1-phosphateD-ribose 1-phosphateguaninephosphateguanosineDeoDR80: GMP + H2O = guanosine + phosphatephosphateguanosineH2OGMPR81: GMP + ATP = GDP + ADPADPGDPATPGMPGmkR83: phosphoenolpyruvate + GDP = pyruvate + GTPpyruvateGTPGDPphosphoenolpyruvatePykR456: RNA(n) + GTP = RNA(n+1) + PPiPPiRNA(n+1)GTPRNA(n)RpoBR85: deoxyguanosine + phosphate = guanine + 2-deoxy-D-ribose 1-phosphate2-deoxy-D-ribose 1-phosphateguaninephosphatedeoxyguanosineDeoDR86: deoxyguanosine + ATP = dGMP + ADPADPdGMPATPdeoxyguanosineYaaFR87: dGMP + ATP = dGDP + ADPADPdGDPATPdGMPGmkR88: phosphoenolpyruvate + dGDP = pyruvate + dGTPpyruvatedGTPdGDPphosphoenolpyruvatePykR457: DNA(n) + dGTP = DNA(n+1) + PPiPPiDNA(n+1)dGTPDNA(n)R78: guanine + 5-phospho-D-ribose 1-PPi = GMP + PPiPPiGMP5-phospho-D-ribose 1-PPiguanineHptR458: GDP + txrB-R'-S-S-R' = dGDP + H2O + OsmC-R'-S-S-R'H2OdGDPOsmC-R'-S-S-R'txrB-R'-S-S-R'GDPNrdFR202: uracil[e] + H+[e]= uracil + H+H+uracilH+[e]uracil[e]R459: uracil + D-ribose 1-phosphate <=> uridine + phosphatephosphateuridineuracilD-ribose 1-phosphateDeoAR111: phosphate + deoxyuridine <=> uracil + 2-deoxy-D-ribose 1-phosphateuracil2-deoxy-D-ribose 1-phosphatephosphatedeoxyuridineDeoAR113: dUMP + H2O = deoxyuridine + phosphatephosphatedeoxyuridinedUMPH2OR112: deoxyuridine + ATP = dUMP + ADPdUMPADPATPdeoxyuridineTdkR189: dUMP + ATP = dUDP + ADPdUDPADPATPdUMPTmkR93: Uridine + ATP = UMP + ADPADPUMPATPuridineUdkR92: UMP + H2O = uridine + phosphatephosphateuridineH2OUMPR94: UMP + ATP = UDP + ADPADPUDPATPUMPPyrHR460: txrB-R'-S-S-R' + H2O + dUDP <=> UDP + txrB-(R'-SH)2UDPtxrB-(R'-SH)2dUDPH2OtxrB-R'-S-S-R'NrdFR95: phosphoenolpyruvate + UDP = pyruvate + UTPUTPpyruvatephosphoenolpyruvateUDPPykR461: RNA(n) + UTP <=> RNA(n+1) + PPiPPiRNA(n+1)UTPRNA(n)RpoBR462: RNA(n+1) + H2O = UMP + RNA(n)UMPRNA(n)H2ORNA(n+1)R90: uracil + 5-phospho-D-ribose 1-PPi = UMP + PPiPPiUMPuracil5-phospho-D-ribose 1-PPiUppR247: deoxycytidine[e] + H+[e] = deoxycytidine + H+H+deoxycytidineH+[e]deoxycytidine[e]R106: deoxycytidine + ATP = dCMP + ADPADPdCMPATPdeoxycytidineYaaFR107: dCMP + H2O = deoxycytidine + phosphatephosphatedeoxycytidineH2OdCMPR208: cytidine[e] + H+[e] = cytidine + H+H+cytidinecytidine[e]H+[e]R100: cytidine + ATP = CMP + ADPADPCMPATPcytidineUdkR101: CMP + H2O = cytidine + phosphatephosphatecytidineH2OCMPR102: CMP + ATP = CDP + H2OCDPATPCMPCmkR108: dCMP + ATP = dCDP + ADPADPdCDPATPdCMPCmkR463: CDP + txrB-(R'-SH)2 = dCDP + txrB-R'-S-S-R' + H2OH2OtxrB-R'-S-S-R'dCDPCDPtxrB-(R'-SH)2R109: phosphoenolpyruvate + dCDP = pyruvate + dCTPpyruvatedCTPphosphoenolpyruvatedCDPPykR464: dCTP + DNA(n) = DNA(n+1) + PPiPPiDNA(n+1)dCTPDNA(n)PolCR103: phosphoenolpyruvate + CDP = pyruvate + CTPCTPpyruvatephosphoenolpyruvateCDPPykR465: CTP + RNA(n) <=> PPi + RNA(n+1)PPiRNA(n+1)CTPRNA(n)RpoBR467: RNA(n+1) + H2O = RNA(n) + CMPCMPRNA(n)H2ORNA(n+1)R98: UTP + ATP + NH3 = CTP + ADP + phosphateADPphosphateCTPATPNH3UTPMpn256R72: PPi + H2O = Pi + PiphosphatePPiH2OPpaR203: thymine[e] + H+[e] = thymine + H+H+thymineH+[e]thymine[e]R115: thymidine + phosphate = thymine + 2-deoxyD-ribose 1-phosphate2-deoxy-D-ribose 1-phosphatethyminephosphatethymidineDeoAR116: thymidine + ATP = dTMP + ADPADPdTMPATPthymidineTdkR468: dTMP + H2O = phosphate + thymidinephosphatethymidinedTMPH2OR118: dTMP + ATP = dTDP + ADPADPdTDPATPdTMPTmkR119: phosphoenolpyruvate + dTDP = pyruvate + dTTPpyruvatedTTPdTDPphosphoenolpyruvatePykR469: dTTP + DNA(n) = DNA(n+1) + PPiPPiDNA(n+1)dTTPDNA(n)PolCR431: dUMP + 5,10-methylenetetrahydrofolate = dTMP + dihydrofolatedTMPdihydrofolatedUMP5,10-methylenetetrahydrofolateThyAR212: pyridoxal[e] = pyridoxalpyridoxalpyridoxal[e]R142: pyridoxal + ATP = pyridoxal 5'-phosphate + ADPADPpyridoxal 5'-phosphateATPpyridoxalR470: thiamine[e] + ATP + H2O = H+ + phosphate + ADP + thiamineADPphosphatethiamineH+ATPthiamine[e]H2OR143: thiamine + ATP = thiamine phosphate + ADPADPthiamine phosphateATPthiamineR144: thiamine phosphate + ATP = thiamine PPi + ADPADPthiamine PPiATPthiamine phosphateThiIR207: riboflavin[e] = riboflavinriboflavinriboflavin[e]R140: riboflavin + ATP = FMN + ADPADPFMNATPriboflavinYaaCR141: FMN + ATP = FAD + PPiPPiFADATPFMNYaaCR229: L-asparagine + H+ = L-asparagine[e] + H+[e]H+L-asparagineH+[e]L-asparagine[e]R257: L-glutamine[e] + H2O + ATP --> L-glutamine + ADP + phosphate + H+ADPH+phosphateL-glutamineATPH2OL-glutamine[e]GlnQR233: L-glutamine + H+ = L-glutamine[e] + H+[e]H+[e]L-glutamine[e]H+L-glutamineR152: glutamyl-tRNA(Gln) + L-glutamine + ATP = glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphateADPphosphateglutaminyl-tRNA(Gln)L-glutamateATPglutamyl-tRNA(Gln)L-glutamineMPN236;MPN237;MPN238GatCGatAGatBR151: glutamyl-tRNA(Gln) + L-asparagine + ATP = glutaminyl-tRNA(Gln) + L-aspartate + ADP + phosphateADPphosphateL-aspartateglutaminyl-tRNA(Gln)ATPglutamyl-tRNA(Gln)L-asparagineMPN236;MPN237;MPN238GatCGatAGatBR432: Amino acid[e] + ATP + H2O = Amino acid + ADP + Pi + H+ADPH+Piamino acidATPH2Oamino acid[e]R471: amino acid + tRNA + ATP = PPi + AMP + aa-tRNAAMPPPiaa-tRNAATP