rpoA
M129
locus
MPN191
function
RNA synthesis
product
DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (Transcriptase subunit alpha)
MW
35970
ec
2.7.7.6
pI
7.5
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
231448 → 232431 (+)
phenotypes of an overexpression
Fast growth and fast acidification [pubmed|31445891]
the protein
catalyzed reaction/ biological activity
RNAn + NTP = RNAn+1 + PPi, reversible reaction
localization
DNA-directed RNA polymerase (according to UniProt)
modification
Acetylated in Lysine, at K316 [pubmed|22373819]
Acetylated in Lysine, at K255 [pubmed|22373819]
Acetylated in Lysine, at K3 [pubmed|22373819]
Acetylated in Lysine, at K6 [pubmed|22373819]
Acetylated in Lysine, at K255 [pubmed|22373819]
Acetylated in Lysine, at K316 [pubmed|22373819]
Acetylated in Lysine, at K266 [pubmed|22373819]
structure
[PDB|5UH5] from Mycobacterium tuberculosis, Crystal structure of transcription initiation complex containing 3 nt of RNA (40% identity) [pubmed|28392175]
[AF|Q50295]
references
reviews
original publications
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Time of last update: 2024-04-21 18:39:32
Author of last update: Jstuelk