mtd1
M129

similar to methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

locus

MPN017

function

formylation of Met-tRNA(fMet)

product

methylenetetrahydrofolate dehydrogenase (NADP)

29590

1.5.1.5; 3.5.4.9

8.23

synonyms

folD

Gene length

810 bp Sequence Blast

Protein length

269 aa Sequence Blast

essential

yes

Outlinks

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0190

This gene is a member of the following regulons

gene

coordinates

18989 → 18180 (-)

the protein

catalyzed reaction/ biological activity

10-formyltetrahydrofolate + H+ = 5,10-methenyltetrahydrofolate + H2O, reversible reaction

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+, reversible reaction

tetrahydrofolate + formate + ATP = 10-formyltetrahydrofolate + ADP + phosphate (novel) , reversible reaction

localization

cytoplasm

cofactors

NADP

structure

[PDB|3L07] from Francisella tularensis, a putative bifunctional protein FolD (31% identity)

[AF|P75096]

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Time of last update: 2024-03-23 15:11:30

Author of last update: Jstuelk