pdhD
M129
locus
MPN390
function
Fermentation
product
Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of pyruvate complex)
MW
50270
ec
1.8.1.4
pI
8.29
essential
no
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
467846 → 466473 (-)
the protein
catalyzed reaction/ biological activity
dihydrolipoamide + NAD+ = lipoamide + NADH + H+, reversible reaction
localization
cytoplasm [pubmed|25978044]
cell membrane [pubmed|25978044]
cell surface [pubmed|25978044]
modification
Acetylated in Lysine, at K328 [pubmed|22373819]
Acetylated in Lysine, at K105 [pubmed|22373819]
Acetylated in Lysine, at K360 [pubmed|22373819]
Acetylated in Lysine, at K92 [pubmed|22373819]
Acetylated in Lysine, at K126 [pubmed|22373819]
Phosphorylated in Ser/Thr, at T145 [pubmed|22373819]
cofactors
FAD
structure
[PDB|1EBD], from Geobacillus stearothermophilus, Dihydrolipoamide dehydrogenase complexed with the binding domain of the Dihydrolipoamide acetylase (39% identity) [pubmed|8805537]
[AF|P75393]
references
reviews
original publications
Page visits: 240
Time of last update: 2025-04-26 02:32:43
Author of last update: Jstuelk