topA
M129
locus
MPN261
function
DNA synthesis/modifications/repair/conformation
product
DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase)
MW
78210
ec
5.99.1.2
pI
9.68
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
312256 → 314391 (+)
the protein
catalyzed reaction/ biological activity
positive coiled dsDNA = dsDNA, reversible reaction
localization
chromosome (according to UniProt)
modification
Acetylated in Lysine, at K686 [pubmed|22373819]
Acetylated in Lysine, at K642 [pubmed|22373819]
Acetylated in Lysine, at K367 [pubmed|22373819]
Acetylated in Lysine, at K604 [pubmed|22373819]
Acetylated in Lysine, at K69 [pubmed|22373819]
Acetylated in Lysine, at K249 [pubmed|22373819]
Acetylated in Lysine, at K572 [pubmed|22373819]
Acetylated in Lysine, at K85 [pubmed|22373819]
Acetylated in Lysine, at K446 [pubmed|22373819]
Acetylated in Lysine, at K691 [pubmed|22373819]
Phosphorylated in Ser/Thr, at SVpSGIDFLDEASAK [pubmed|22373819]
protein family
topo IA family
structure
[PDB|6PCM], from Mycobacterium smegmatis, 32.2% identity [pubmed|32232337]
[AF|P78032]
references
reviews
original publications
Page visits: 294
Time of last update: 2024-03-29 03:23:02
Author of last update: Jstuelk