spoT
M129
locus
MPN397
function
Signal transduction
product
Probable guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC 3.1.7.2) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)
MW
79200
ec
3.1.7.2
pI
9.74
synonyms
[gene|search|relA]
essential
no
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
476509 → 478671 (+)
the protein
catalyzed reaction/ biological activity
ppGpp + H20 = GDP + PPi, reversible reaction
ppGpp + H20 = GTP + PPi, reversible reaction
GTP + ATP = pppGpp + AMP, reversible reaction
localization
cytoplasm
modification
Acetylated in Lysine, at K501 [pubmed|22373819]
Phosphorylated in Ser/Thr, at S373 [pubmed|22373819]
structure
[PDB|5IQR], from Escherichia coli, Structure of RelA bound to the 70S ribosome (24% identity) [pubmed|27279228]
[AF|P75386]
references
reviews
original publications
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Time of last update: 2024-02-29 15:45:07
Author of last update: Jstuelk