hapE
M129
cysteine desulfurase activity producing alanine and cysteine desulfhydrase activity producing pyruvate and hydrogen sulfide
locus
MPN487
function
protein homeostasis/pathogenesis
product
cysteine desulfurase /D-cysteine desulfhydrase
MW
44880
ec
2.8.1.7;4.4.1.15
pI
10.06
synonyms
HapE, nifS
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
590569 → 591795 (+)
the protein
catalyzed reaction/ biological activity
L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine, reversible reaction
L-cisteyne + H2O = pyruvate + hydrogensulfide + NH3 + pyruvate, reversible reaction
localization
cytoplasm
structure
[PDB|5FT8] (from Escherichia coli, Crystal structure of the complex between the cysteine desulfurase CsdA and the sulfur-acceptor CsdE in the persulfurated state at 2.50 Angstroem resolution (31% identity)
[AF|P75298]
references
Page visits: 298
Time of last update: 2024-04-13 07:25:54
Author of last update: Taki