pyk
M129
locus
MPN303
function
Glycolysis
product
Pyruvate kinase (PK) (EC 2.7.1.40)
MW
55880
ec
2.7.1.40
pI
9.56
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
This gene is a member of the following regulons
gene
coordinates
356677 → 358203 (+)
phenotypes of an overexpression
slow acidification [pubmed|31445891]
the protein
catalyzed reaction/ biological activity
phosphoenolpyruvate + ADP = pyruvate + ATP, reversible reaction
phosphoenolpyruvate + dADP = pyruvate + dATP, reversible reaction
phosphoenolpyruvate + GDP = pyruvate + GTP, reversible reaction
phosphoenolpyruvate + dGDP = pyruvate + dGTP, reversible reaction
phosphoenolpyruvate + UDP = pyruvate + UTP, reversible reaction
phosphoenolpyruvate + CDP = pyruvate + CTP, reversible reaction
phosphoenolpyruvate + dCDP = pyruvate + dCTP, reversible reaction
phosphoenolpyruvate + dTDP = pyruvate + dTTP, reversible reaction
localization
membrane [pubmed|26667841]
modification
Acetylated in Lysine, at K202 [pubmed|22373819]
Acetylated in Lysine, at K504 [pubmed|22373819]
Acetylated in Lysine, at K475 [pubmed|22373819]
Acetylated in Lysine, at K249 [pubmed|22373819]
Acetylated in Lysine, at K294 [pubmed|22373819]
Acetylated in Lysine, at K107 [pubmed|22373819]
Acetylated in Lysine, at K184 [pubmed|22373819]
cofactors
CO2
structure
[PDB|5YNG], from Escherichia coli, Crystal structure analysis of pyruvate kinase (35% identity) [pubmed|29232125]
[AF|P78031]
references
Page visits: 356
Time of last update: 2024-05-10 05:25:35
Author of last update: Jstuelk