dyr
M129
locus
MPN300
function
Cell division, biosynthesis of folate
product
Dihydrofolate reductase (EC 1.5.1.3) and segregation and condensation protein A, ScpA
MW
55660
ec
1.5.1.3
pI
8.4
synonyms
scpA
essential
yes
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0262,COG1354
This gene is a member of the following regulons
gene
coordinates
353535 → 355055 (+)
phenotypes of an overexpression
Slow growth [pubmed|31445891]
Slow acidification [pubmed|31445891]
the protein
catalyzed reaction/ biological activity
folate + NADH + H+ = dihydrofolate + NAD+ (novel) , reversible reaction
dihydrofolate + NADH + H+ = tetrahydrofolate + NAD+ (novel) , reversible reaction
localization
cytoplasm (according to UniProt)
structure
[PDB|3IX9], from Streptococcus pneumoniae, Crystal structure of dihydrofolate reductase - Sp9 mutant (29% identity) [pubmed|28714993]
[AF|P75478]
references
reviews
original publications
Page visits: 176
Time of last update: 2025-09-26 07:26:04
Author of last update: Jstuelk