mthfs

mthfs
M129

locus
MPN348
function
detoxification of 5-formyl-THF
product
5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2)
MW
18040
ec
6.3.3.2
pI
7.25
Gene length
495 bp Sequence Blast
Protein length
164 aa Sequence Blast
essential
no
Outlinks
UniProt STRING PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0212

This gene is a member of the following regulons

gene
coordinates
416070 → 416564 (+)
the protein
catalyzed reaction/ biological activity
converts toxic 5-formyl-THF (side product of [protein|dc3d780dbd23fe2d189d0a4f28ca7cf3ff979c11|GlyA]) back to 5,10-methenyl-THF
localization
cytoplasm (according to UniProt)
modification
Acetylated in Lysine, at K120 [pubmed|22373819]
structure
[PDB|1SBQ], from Mycoplasma pneumoniae, Crystal Structure of methenyltetrahydrofolate synthetase (100% identity) [pubmed|15281135]
[AF|P75430]
references
15281135,21538139,22373819

f36cb347ee929cae14d0d7cefbe07995ae80322f

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Time of last update: 2024-05-05 21:17:30

Author of last update: Jstuelk