dnaK

dnaK
M129

heat-shock protein (molecular chaperone)

locus
MPN434
function
Protein homeostasis
product
Chaperone protein DnaK (Heat shock protein 70, HSP70)
MW
65450
pI
5.16
Gene length
1788 bp Sequence Blast
Protein length
595 aa Sequence Blast
essential
yes
Outlinks
UniProt STRING PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0443

This gene is a member of the following regulons

gene
coordinates
523624 → 521837 (-)
the protein
catalyzed reaction/ biological activity
DnaK-ATP + DnaJ-protein = DnaK-ADP-DnaJ-Protein + Pi, reversible reaction
DnaK-ADP-DnaJ-Protein + GrpE = DnaK-DnaJ-Protein + ADP + GrpE, reversible reaction
DnaK-DnaJ-Protein + ATP = DnaK-ATP + DnaJ + Protein, reversible reaction
localization
cytoplasm
modification
Acetylated in Lysine, at K84 [pubmed|22373819]
Acetylated in Lysine, at K574 [pubmed|22373819]
Acetylated in Lysine, at K290 [pubmed|22373819]
Acetylated in Lysine, at K290 [pubmed|22373819]
Acetylated in Lysine, at K567 [pubmed|22373819]
Acetylated in Lysine, at K567 [pubmed|22373819]
Acetylated in Lysine, at K308,K310 [pubmed|22373819]
Acetylated in Lysine, at K284 [pubmed|22373819]
Acetylated in Lysine, at K541 [pubmed|22373819]
Acetylated in Lysine, at K112 [pubmed|22373819]
Acetylated in Lysine, at K565 [pubmed|22373819]
Acetylated in Lysine, at K166 [pubmed|22373819]
Acetylated in Lysine, at K279 [pubmed|22373819]
Acetylated in Lysine, at K504 [pubmed|22373819]
Acetylated in Lysine, at K91 [pubmed|22373819]
Acetylated in Lysine, at K537 [pubmed|22373819]
Acetylated in Lysine, at K310 [pubmed|22373819]
Acetylated in Lysine, at K504 [pubmed|22373819]
Acetylated in Lysine, at K331 [pubmed|22373819]
Acetylated in Lysine, at K142 [pubmed|22373819]
Acetylated in Lysine, at K528 [pubmed|22373819]
Acetylated in Lysine, at K549 [pubmed|22373819]
Phosphorylated in Ser/Thr, at LVEpSMVPGHSPNR [pubmed|22373819]
Phosphorylated in Ser/Thr, at S525/ T526 [pubmed|22373819]
Phosphorylated in Ser/Thr, at RNTpTIPVSK [pubmed|22373819]
Phosphorylated in Ser/Thr, at T551 [pubmed|22373819]
cofactors
Mg2+
structure
[PDB|5OBU], from Mycoplasma genitalium, DnaK deletion mutant lacking SBDalpha in complex with AMPPNP (95% identity) [pubmed|29520883]
[AF|P75344]
references
29520883,22373819

8d5ae179cbbc245af3f36f9cd2aedebbb5c3e480

Page visits: 241

Time of last update: 2025-08-02 21:52:15

Author of last update: Jstuelk